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Related Experiment Videos

Stable quantitative EEG difference in post-LSD visual disorder by split-half analysis: evidence for disinhibition

H D Abraham1, F H Duffy

  • 1Department of Psychiatry, Tufts University School of Medicine, New England Medical Center, Boston, MA 02111, USA. habraham@opal.tufts.edu

Psychiatry Research
|October 7, 1996
PubMed
Summary

Hallucinogen persisting perceptual disorder (HPPD) is linked to altered brain activity. Quantitative EEG revealed distinct visual and auditory processing differences in HPPD patients compared to controls.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Hallucinogen persisting perceptual disorder (HPPD) is a condition characterized by persistent visual disturbances after hallucinogen use.
  • LSD and other hallucinogens can induce these perceptual changes in a subset of individuals.

Purpose of the Study:

  • To investigate quantitative EEG (qEEG) differences between individuals with LSD-induced HPPD and matched controls.
  • To explore spectral and evoked potential differences to understand the neurophysiological underpinnings of HPPD.

Main Methods:

  • Quantitative EEG (qEEG) analysis was performed on 44 individuals with LSD-induced HPPD and 88 controls.
  • Included spectral analysis and evoked potential measures like visual evoked response (VER) and auditory evoked response (AER).

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  • Employed T-statistic significance probability mapping (T-SPM) for spatial analysis and discriminant analysis for classification.

    • Main Results:

    • HPPD subjects showed faster alpha frequency and shorter visual evoked response (VER) latency.
    • Auditory evoked response (AER) latency was prolonged in HPPD subjects, suggesting differential effects on visual and auditory systems.
    • T-SPM identified significant differences in temporal and left parietal regions, primarily from long-latency VER and click AER.
    • No spectral EEG data differentiated the groups.

    Conclusions:

    • qEEG measures, particularly evoked potentials, can differentiate individuals with HPPD from controls.
    • Findings suggest LSD-induced cortical disinhibition and differential impacts on sensory processing in HPPD.
    • The study achieved high classification success rates, indicating the potential of qEEG as a diagnostic tool for HPPD.