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Antimicrobial susceptibility pattern of Corynebacterium striatum
L Martínez-Martínez1, A Pascual, K Bernard
1Department of Microbiology, Hospital Universitario Virgen Macarena, Seville, Spain.
Antimicrobial Agents and Chemotherapy
|November 1, 1996
Summary
Teicoplanin and vancomycin show potent in vitro activity against Corynebacterium striatum. Most beta-lactams are also effective, while amikacin, erythromycin, and rifampin demonstrate limited efficacy against these strains.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Corynebacterium striatum is an opportunistic pathogen.
- Understanding its antimicrobial susceptibility is crucial for effective treatment.
Purpose of the Study:
- To evaluate the in vitro antimicrobial activity of various agents against Corynebacterium striatum.
- To determine the minimum inhibitory concentrations (MICs) for key antibiotics.
Main Methods:
- Microdilution method was employed.
- Cation-adjusted Mueller-Hinton broth was used as the growth medium.
- 16 antimicrobial agents were tested against 86 clinical isolates.
Main Results:
- Teicoplanin exhibited the lowest MIC (0.06 µg/ml).
- Vancomycin (1 µg/ml) and beta-lactams (0.03–8 µg/ml) were also effective.
- Sparfloxacin, ciprofloxacin, co-trimoxazole, tetracycline, and gentamicin showed moderate to high MICs.
- Amikacin, erythromycin, and rifampin displayed poor activity (MICs > 128 µg/ml).
Conclusions:
- Teicoplanin and vancomycin are promising therapeutic options for Corynebacterium striatum infections.
- Beta-lactams remain a viable treatment choice.
- Resistance to amikacin, erythromycin, and rifampin necessitates alternative therapeutic strategies.