Related Experiment Video
Updated: Aug 18, 2026

Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy
Published on: April 9, 2018
[Collagen biosynthesis in the arterial wall in experimental atherosclerosis]
Abstract:
The authors examined collagenous neosynthesis in the aortic wall of rats with experimental atherosclerosis after application of 3H-proline, a precursor of collagen, as well as subsequent determination of the radioactivity in the aortic wall by means of scintiliation counting and localization of the incorporated radioisotope by radioautography (optical and electron microscopic). There was a great increase of the incorporation of 3H-proline in the atherosclerotic aortas in comparison with controls, a manifestation of raised neosynthesis of collagen in the cellular elements of the aortic wall in atherosclerosis. The elevated collagenogenosis was due mainly to an increased synthetic activity of the modified smooth muscle cells, forming fibrous atherosclerotic plaques. This was proven by their more intensive radioisotopic marking in comparison with medial smooth muscle cells in the optical and electrone microscopic radioautograms.
More Related Videos
09:06Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
13:45A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
Published on: November 11, 2022
Related Concept Videos
Inflammation
Type IV Collagen of Basal Lamina
A type IV collagen molecule has six alpha chains which can exist in...
Coronary Artery Disease II: Pathophysiology
Atherosclerosis I: Introduction
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests