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The human intestinal H+/oligopeptide cotransporter hPEPT1 transports differently-charged dipeptides with identical
B Mackenzie1, Y J Fei, V Ganapathy
1Department of Physiology, UCLA School of Medicine 90095-1751, USA.
Biochimica Et Biophysica Acta
|October 23, 1996
Abstract:
The human intestinal H+/oligopeptide cotransporter hPEPT1, expressed in Xenopus oocytes, transported neutral, anionic and cationic dipeptides with identical electrogenic properties and maximal evoked currents. Currents were activated by 1 H+ regardless of the net charge on the driven substrate, and were independent of Na+o, K+i and Clo-, calling into question the familiar concept of the origin of the transporter-mediated current.