[Neurophysiological study in the cat of 2 substituted benzamides : sulpiride and sultopride]

Using three distinct electrophysiological tests in unanesthetized cat preparations (hippocampal theta, " caudat spindles " and stereotyped hind limb locomotor rhythms) two psychotropic benzamide derivatives (Sulpirid and Sultoprid) were tested both through systemic administration and local intracerebral microinjections. Our conclusions are that : a) Sulpirid activates the limbic system and locomotor rhythms, while deafferenting the higher " telodiencephalic " structures ; b) Sultoprid is, in revanche, at the same time deafferenting higher structure and depressing the lower one; c ) the hypothalamus represents one of the preferential targets for action of these substances.