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Prodynorphin mRNA expression in the rat dentate gyrus after cerebral ischemia
A Héron1, E Traiffort, M Allix
1Laboratoire de Physiologie, Faculté de Pharmacie, Université René Descartes, Paris, France.
Neuropeptides
|August 1, 1996
Abstract:
The beneficial effects of exogenous kappa receptor agonists in preventing neuronal damage elicited by brain ischemia suggest a role for endogenous dynorphins. In agreement prodynorphin (PDYN) gene expression in granule cells of the dentate gyrus detected by in situ hybridization was drastically but transiently decreased 18-32 h after four-vessel cerebral ischemia for 20 min in rats. We propose that decreased dynorphin synthesis and release could contribute to the delayed neuronal death of hippocampal pyramidal cells in this model.