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Leukocyte-endothelial cell interactions evoked by mast cells
1Immunology Research Group, University of Calgary Medical Center, Alberta, Canada.
Cardiovascular Research
|October 1, 1996
Summary
Mast cells are critical for recruiting leukocytes to inflammation sites. This review details how mast cell activation drives leukocyte recruitment in various inflammatory conditions, including IgE-independent responses.
Area of Science:
- Immunology
- Cell Biology
Background:
- Mast cells are key players in inflammatory responses.
- Leukocyte recruitment is a fundamental process in inflammation.
Purpose of the Study:
- To review evidence supporting mast cells' role in leukocyte recruitment.
- To discuss mechanisms and mediators involved in mast cell-induced leukocyte recruitment.
Main Methods:
- Review of pharmacological studies (e.g., compound 48/80).
- Analysis of data from delayed-type hypersensitivity reactions.
- Examination of IgE-independent and pathogen-induced inflammation models.
Main Results:
- Compound 48/80 induces multi-step leukocyte recruitment via mast cell activation.
- Mast cells are implicated in delayed-type hypersensitivity and IgE-independent recruitment.
- Ischemia/reperfusion and bacterial toxin-induced recruitment are mast cell-dependent.
Conclusions:
- Mast cells critically regulate leukocyte recruitment in diverse inflammatory settings.
- Further research into mast cell modulation, including nitric oxide's role, is warranted.