Elimination of ioversol by hemodialysis

The dialysability of ioversol was investigated in 12 patients with chronic renal failure, on 4-h hemodialysis.

One hundred ml of ioversol (320 mg I/ml) was injected in less than 10 min during CT. Hemodialysis was commenced within 30 min of starting the contrast medium injection and was continued for 4 h. Blood was sampled before and at 15 min, 30 min, 1 h, 2 h, and 4 h after the start of hemodialysis. Mean dialysance of ioversol was 114 to 129 ml/min and the elimination rate was 82.5 +/- 5.1% 4 h after starting hemodialysis. The half-life of ioversol during hemodialysis was 1.80 +/- 0.38 h. The only side effects of the ioversol injection were heat sensations, which were experienced by 3 patients.

As ioversol was effectively removed from the body during the 4 h of hemodialysis and no severe adverse reactions were observed, we conclude that ioversol is suitable for use in hemodialyzed patients.