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Biliary dyskinesia in idiopathic slow-transit constipation
D Hemingway1, J B Neilly, I G Finlay
1Department of Coloproctology, Royal Infirmary, Glasgow, United Kingdom.
Diseases of the Colon and Rectum
|November 1, 1996
Summary
Idiopathic slow-transit constipation may involve the entire digestive system. Patients with this condition show significantly lower gallbladder ejection fraction, suggesting a broader motility issue.
Area of Science:
- Gastroenterology
- Motility Disorders
- Biliary System Physiology
Background:
- Idiopathic slow-transit constipation (ISTC) is a challenging condition.
- It is increasingly recognized as a potential pangastrointestinal motility disorder.
- This study investigated a potential link between ISTC and biliary dyskinesia.
Purpose of the Study:
- To screen patients with constipation for surgical referral for biliary dyskinesia.
- To determine if ISTC is associated with impaired gallbladder function.
- To explore the hypothesis of ISTC as a pangastrointestinal motility disorder.
Main Methods:
- Patients referred for constipation surgery were evaluated.
- Cholecystokinin-augmented trimethyl-3-bromo iminodiacetic acid scans were performed.
- Gallbladder ejection fraction (GBEF) was measured.
Main Results:
- A significant difference in GBEF was observed between patient groups.
- Patients with ISTC had a median GBEF of 28.5.
- Patients with other constipation causes had a median GBEF of 71 (P = 0.0025).
Conclusions:
- Idiopathic slow-transit constipation may be a pangastrointestinal motility disorder.
- Impaired gallbladder motility (biliary dyskinesia) is associated with ISTC.
- These findings suggest a systemic approach to managing ISTC.