Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells

Mrc1 transduces signals of DNA replication stress to activate Rad53.

Nature cell biology·2001

MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint.

Molecular biology of the cell·2001

Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.

The EMBO journal·2001

Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus.

The EMBO journal·2001

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint.

Nature·2001

DNA replication: building the perfect switch.

Current biology : CB·2001

The hnRNPA1 D262V amyotrophic lateral sclerosis (ALS) mutation is linked to mitochondrial dysfunction.

Genes & development·2026

Lymphatics-epicardial cross talk via Reelin controls cardiac growth.

Genes & development·2026

Sharp cell type boundaries emerge from coordinated morphogen signaling.

Genes & development·2026

Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity.

Genes & development·2026

A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer.

Genes & development·2026

Regulatory circuits that build and sustain noninfectious granulomas.

Genes & development·2026

Towards an integrative neuroscience of metacognition.

Nature reviews. Neuroscience·2026

Combating Overfitting of Adversarial Training Efficiently via Balanced Instance Adaptive Defense.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society·2026

Wavelet-prior-guided mamba network for accurate and efficient rice disease recognition.

Frontiers in plant science·2026

Beyond predictive accuracy: A case for mechanism-informed, uncertainty-aware machine learning in food microbiology.

iScience·2026

Interpretable machine learning model based on multimodal MRI radiomics for Alzheimer's disease diagnosis.

Frontiers in aging neuroscience·2026

GMoE-AD: Generalized Hyperspectral Anomaly Detection via Mixture-of-Experts and Domain-Invariant Learning.

Sensors (Basel, Switzerland)·2026

Related Experiment Videos

Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells

Related Concept Videos

Mrc1 transduces signals of DNA replication stress to activate Rad53.

MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint.

Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.

Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus.

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint.

DNA replication: building the perfect switch.

The hnRNPA1 D262V amyotrophic lateral sclerosis (ALS) mutation is linked to mitochondrial dysfunction.

Lymphatics-epicardial cross talk via Reelin controls cardiac growth.

Sharp cell type boundaries emerge from coordinated morphogen signaling.

Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity.

A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer.

Regulatory circuits that build and sustain noninfectious granulomas.

Towards an integrative neuroscience of metacognition.

Combating Overfitting of Adversarial Training Efficiently via Balanced Instance Adaptive Defense.

Wavelet-prior-guided mamba network for accurate and efficient rice disease recognition.

Beyond predictive accuracy: A case for mechanism-informed, uncertainty-aware machine learning in food microbiology.

Interpretable machine learning model based on multimodal MRI radiomics for Alzheimer's disease diagnosis.

GMoE-AD: Generalized Hyperspectral Anomaly Detection via Mixture-of-Experts and Domain-Invariant Learning.

Related Experiment Videos

Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells

Related Concept Videos

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