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Antibiotic resistance pattern and R-plasmids of Acinetobacter calcoaceticus subsp. anitratus
Indian Journal of Pathology & Microbiology
|April 1, 1995
Summary
This study on Acinetobacter calcoaceticus subsp. anitratus found high resistance to certain antibiotics. However, Ceftazidime and Netilmycin showed significant sensitivity, indicating potential treatment options.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Acinetobacter calcoaceticus subsp. anitratus is an opportunistic pathogen.
- Understanding its antibiotic resistance patterns is crucial for effective treatment.
- R-plasmids contribute to the spread of antibiotic resistance.
Purpose of the Study:
- To determine the antibiotic resistance patterns of Acinetobacter calcoaceticus subsp. anitratus strains.
- To investigate the prevalence of R-plasmids in these isolates.
Main Methods:
- Antibiotic susceptibility testing using the Kirby-Bauer method for 12 drugs.
- Conjugation experiments to detect R-plasmids using Nalidixic acid resistant E. coli K12F-Lac+.
Main Results:
- High resistance observed against Chloramphenicol and Tetracycline.
- Ceftazidime and Netilmycin demonstrated the highest sensitivity.
- The commonest resistance pattern was ACGKSTSu.
- R-plasmids were detected in 81.25% of tested isolates.
Conclusions:
- Acinetobacter calcoaceticus subsp. anitratus exhibits significant antibiotic resistance.
- Ceftazidime and Netilmycin are potential therapeutic choices.
- High incidence of R-plasmids suggests a mechanism for resistance dissemination.