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A lymphatic function of Daflon 500 mg
1IRIS, Courbevoie, France.
Summary
Daflon 500 mg, a flavonoidic fraction, significantly increases lymphatic flow in dogs and rats. This enhanced lymphatic drainage may contribute to its effectiveness in treating perivascular edema.
Area of Science:
- Pharmacology
- Physiology
Background:
- Micronized purified flavonoidic fraction (Daflon 500 mg) contains diosmin and hesperidin.
- The lymphagogue activity of Daflon 500 mg has not been fully elucidated.
Purpose of the Study:
- To investigate the lymphagogue activity of Daflon 500 mg.
- To assess the blood-to-lymph transfer of diosmin.
Main Methods:
- Lymphatic flow was measured in anesthetized dogs via thoracic duct fistula after intravenous injection of Daflon 500 mg.
- 14C-diosmin transfer from blood to lymph was studied in dogs.
- Similar experiments were conducted in rats following oral administration.
Main Results:
- Daflon 500 mg significantly increased lymphatic flow in a dose-dependent manner.
- A correlation was observed between increased lymphatic flow and pulsatility.
- Evidence suggested active transport of diosmin from blood to lymph.
Conclusions:
- Daflon 500 mg exhibits significant lymphagogue activity.
- Improved lymphatic drainage is a likely mechanism for Daflon 500 mg's efficacy in perivascular edema.