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Molecular characterization of a nonneuronal human UNC18 homolog
S F Ziegler1, M T Mortrud, A R Swartz
1Darwin Molecular Corporation, Bothell, Washington 98021, USA. ziegler@darwin.com
Genomics
|October 1, 1996
Abstract:
A cDNA clone encoding a human homolog of the Caenorhabditis elegans unc-18 gene was identified following random sequencing of clones from IL-2-activated human NK cells. This cDNA clone is related to the nonneuronal Munc-18b and so has been called Hunc-18b. The Hunc-18b transcripts were found in most human tissues, with the exception of brain and skeletal muscle, and in cells from all lymphoid lineages. The Hunc-18b gene was localized to human chromosome 19p13.2-p13.3, and the mouse homolog, Munc-18b, was mapped to the proximal region of mouse Chromosome 8.