I-123 iodoamphetamine scintigraphic detection of bone metastases from malignant melanoma

Widely used for cerebral perfusion imaging, I-123 iodoamphetamine (I-123 IMP) is also known to accumulate in malignant melanomas. A case of malignant melanoma is presented, in which I-123 IMP scintigraphy was useful to visualize the bone metastases. During the period of postoperative follow-up, multiple foci of increased I-123 IMP uptake appeared in the skeleton. Conventional bone scintigraphy was less striking, showing cold defects or irregular radionuclide uptake.