Interferon gamma in trauma-related infections
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Updated: Oct 2, 2026

Expansion of Human Peripheral Blood γδ T Cells using Zoledronate
Published on: September 9, 2011
1Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, USA.
Objective:
The efficacy of interferon gamma therapy in reducing infection and improving outcome from infection in patients sustaining major injury was examined.
Design:
Randomized double-blind placebo control trial
Setting:
Nine level one university affiliated trauma centers in the United States.
Patients And Participants:
Four hundred sixteen patients with injury severity score (ISS) > or = 25 or ISS > or = 20 with evidence of wound contamination.
Intervention:
Recombinant human interferon gamma 100 ug or placebo was given subcutaneously daily for up to 21 days in addition to standard antibiotic therapy.
Measurements And Results:
Comparable rates of major and minor infections were observed. Among the patients treated with interferon gamma there were fewer deaths related to major infection regardless of type [7-(3%) vs 18-(9%)]. The results, however, were dominated by one center which had the highest enrollment, infection and death rates.
Conclusions:
Further studies are warranted to investigate the role of interferon gamma therapy in improving outcome with major infection.
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