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The nervous system in systemic sclerosis (scleroderma). Clinical features and pathogenetic mechanisms
M M Cerinic1, S Generini, A Pignone
1Institute of Internal Medicine IV, University of Florence, Italy.
Rheumatic Diseases Clinics of North America
|November 1, 1996
Summary
The nervous system, particularly the autonomic nervous system (ANS), is an early target in Systemic Sclerosis (SSc) affecting the gastrointestinal tract. Understanding this neurological involvement is key to grasping SSc
Area of Science:
- Neurology
- Gastroenterology
- Immunology
Background:
- Nervous system involvement in Systemic Sclerosis (SSc) is increasingly recognized.
- Diverse neurological manifestations occur in SSc, including mononeuritis and carpal tunnel syndrome.
- The autonomic nervous system (ANS) is identified as an early site of SSc pathology within the gastrointestinal tract.
Purpose of the Study:
- To highlight the significance of early ANS involvement in SSc pathogenesis.
- To underscore the role of the nervous system in the development and progression of SSc.
Main Methods:
- Review of current literature on neurological manifestations in SSc.
- Analysis of pathogenetic mechanisms underlying nervous system damage in SSc.
Main Results:
- The autonomic nervous system (ANS) is demonstrably the earliest structure affected by SSc in the gastrointestinal system.
- Evidence suggests a critical role for nervous system dysfunction in the multifaceted presentation of SSc.
Conclusions:
- Early ANS targeting in the GI tract is a crucial, though under-interpreted, aspect of SSc.
- Further understanding of nervous system involvement may be pivotal for comprehending SSc onset, progression, and maintenance.