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Updated: Jul 18, 2026

Preparation of Polyoxometalate-based Photo-responsive Membranes for the Photo-activation of Manganese Oxide Catalysts
Published on: August 7, 2018
Lipid peroxidation in workers exposed to manganese
Manganese exposure in workers increases plasma manganese and malondialdehyde, a marker of lipid peroxidation. Higher malondialdehyde levels in exposed workers strongly correlate with increased plasma manganese, suggesting its utility as an indicator of manganese-induced oxidative stress.
Area of Science:
- Occupational health
- Biochemistry
- Toxicology
Background:
- Manganese exposure is a concern in occupational settings.
- Lipid peroxidation is a marker of oxidative stress.
- Antioxidant enzymes play a protective role against oxidative damage.
Purpose of the Study:
- To test the hypothesis that plasma manganese concentration is positively associated with lipid peroxidation.
- To investigate the relationship between lipid peroxidation and antioxidant enzyme activity in manganese-exposed workers.
Main Methods:
- Plasma manganese concentration was measured using graphite furnace atomic absorption spectrophotometry.
- Malondialdehyde (lipid peroxidation product) was quantified by high-performance liquid chromatography.
- Activities of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, catalase) were determined spectrophotometrically.
Main Results:
- Manganese-exposed workers exhibited significantly higher plasma manganese and malondialdehyde concentrations compared to referents.
- A strong positive correlation was observed between plasma malondialdehyde and manganese levels in exposed workers.
- Superoxide dismutase activity was also significantly higher in the exposed group.
Conclusions:
- Malondialdehyde serves as a reliable biomarker for manganese-induced lipid peroxidation.
- The findings support the link between manganese exposure, oxidative stress, and lipid peroxidation.
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