[Pathophysiological basis of aminoglycoside-induced ototoxicity]

Recently proposed etiopathological mechanisms of aminoglycoside-induced toxicity were reviewed, including calcium, phosphatidylinositol, Na-K dependent ATPase, and neuronal sites of antibiotic action. Difficulties in evaluating the true clinical incidence of this aminoglycoside-induced ototoxicity and risk factors were analyzed. The relation between new dosing regimens (single daily dose) and ototoxicity are discussed.