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Updated: Aug 13, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
[Endogenous body rhythms as a modulating factor for parameters of stimulation]
Abstract:
The supposition about increased efficiency of sensory stimulation in the case of feedback control of its parameters by patient's own endogenous rhythm is experimentally tested. Transcutaneous electric nerve stimulation with parameters being feedback controlled by patient's respiratory rhythm was used as a model in 12 male volunteers suffering from different ethiology pain. Significant activation of low frequency (8 divided by 10 Hz) alpha electroencephalogram components, deepening of breath, the decrease of both muscle tension and galvanic skin response amplitudes, as well as pronounced pain relief effects together with increase of functional state and mood levels were the results of such transcutaneous electric nerve stimulation modification.

