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'Malignant' middle cerebral artery territory infarction: clinical course and prognostic signs
Insights
Complete middle cerebral artery territory infarction has a very poor prognosis, often leading to brain death. Early clinical and imaging data can predict outcomes within hours of symptom onset.
Area of Science:
- Neurology
- Vascular Neurology
- Stroke Medicine
Background:
- Limited prospective data exist on the clinical course of complete middle cerebral artery (MCA) territory infarction.
- Predisposing factors for herniation and brain death in these cases are not well-established.
Purpose of the Study:
- To evaluate the clinical course of patients with complete MCA territory infarction.
- To identify factors predicting herniation and poor outcomes.
Main Methods:
- Prospective evaluation of 55 patients with complete MCA territory infarction.
- Assessment using Scandinavian Stroke Scale (SSS) and Glasgow Coma Scale (GCS).
- Serial CT scans for midline shift and vascular imaging (angiography/Doppler) for occlusion, with Barthel Index for functional outcome.
Main Results:
- Embolic infarction was presumed in all cases.
- Mean SSS score was 20; deterioration occurred within 2-5 days.
- 22% survival rate; 78% died from transtentorial herniation and brain death.
Conclusions:
- Prognosis for complete MCA territory stroke is extremely poor.
- Early clinical and neuroradiological data predict outcomes within hours.
- Rapidly developing space-occupying effect leads to herniation in most cases.
Background:
Although the clinical features of space-occupying ischemic stroke are well known, there are limited prospective data on the clinical course of complete middle cerebral artery territory infarction and on the predisposing factors leading to subsequent herniation and brain death.
Methods:
The clinical course of patients with complete middle cerebral artery territory infarction, defined by computed tomography and vascular imaging, was evaluated. Initial clinical presentation was assessed by the Scandinavian Stroke Scale and the Glasgow Coma Scale. Serial computed tomography with measurement of midline and septum pellucidum shift and data on the presence and location of vascular occlusion by angiography or Doppler ultrasound were obtained directly after admission. Time course and outcome were analyzed with regard to the clinical findings on admission and at follow-up. The functional status of surviving patients was assessed using the Barthel Index.
Results:
Fifty-five patients with complete middle cerebral artery territory infarction caused by occlusion of either the distal intracranial carotid artery or the proximal middle cerebral artery trunk were studied. In all patients, embolic infarction was presumed. The mean Scandinavian Stroke Scale score on admission was 20, and the time course of deterioration varied between 2 and 5 days. Forty-nine patients required ventilator assistance during the acute stage of disease. Only 12 patients (22%) survived the infarct. The cause of death was transtentorial herniation with subsequent brain death in 43 patients. Survivors had a mean Barthel Index score of 60 (range, 45 to 70).
Conclusions:
The prognosis of complete middle cerebral artery territory stroke is very poor and can be estimated by early clinical and neuroradiological data within the first few hours after the onset of symptoms. A space-occupying mass effect develops rapidly and predictably over the initial 5 days after presentation. Herniation occurred as an end point in 43 (78%) of these patients.