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Related Experiment Videos

Biliary excretion studies with digoxin in man

U Klotz, K H Antonin

    International Journal of Clinical Pharmacology and Biopharmacy
    |July 1, 1977
    PubMed
    Summary

    Digoxin biliary excretion is minimal, with only 2-10% of the daily dose eliminated via bile in patients with a T-tube. Cholestyramine did not affect digoxin pharmacokinetics, suggesting insignificant enterohepatic cycling of this cardiac glycoside.

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    Area of Science:

    • Pharmacology
    • Gastroenterology

    Background:

    • Digoxin is a cardiac glycoside with a narrow therapeutic index.
    • Understanding its elimination pathways is crucial for optimizing patient therapy.

    Purpose of the Study:

    • To quantify the biliary excretion of digoxin in patients with a T-tube.
    • To investigate the effect of cholestyramine on digoxin pharmacokinetics.

    Main Methods:

    • Biliary excretion of digoxin was measured in 4 patients with a T-tube over 48 hours.
    • A crossover study in 2 volunteers assessed the impact of cholestyramine on digoxin plasma levels.

    Main Results:

    • Biliary excretion of digoxin ranged from 8.8% to 9.2% within 36 hours after a single dose.
    • During steady-state, 2-10% of the daily digoxin dose was excreted in bile.
    • Cholestyramine did not alter digoxin plasma level time profiles.

    Conclusions:

    • Bile excretion accounts for minor amounts of digoxin elimination.
    • Enterohepatic cycling of digoxin is likely insignificant.
    • These findings support current understanding of digoxin's pharmacokinetic profile.

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