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Glomerular localization of interleukin-6 suppressed by steroid mini-pulse therapy in an IgA nephropathy patient
Y Taniguchi1, N Yorioka, H Oda
1Second Department of Internal Medicine, Hiroshima University School of Medicine.
Internal Medicine (Tokyo, Japan)
|December 1, 1995
Abstract:
A 16-year-old female with IgA nephropathy harboring histologically active lesions was treated with steroid mini-pulse therapy. Immunohistochemical examination revealed a diffuse distribution of interleukin-6 (IL-6) in the renal biopsy tissue. After treatment, her clinical factors and renal function improved, and renal biopsy showed reduced histological lesions and disappearance of the IL-6 distribution. Immunohistological studies of cytokines, such as IL-6, may be useful for evaluating the therapeutic effects in IgA nephropathy.