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Corticobasal degeneration: MR with histopathologic comparison
A M Tokumaru1, T O'uchi, Y Kuru
1Department of Radiology, Kameda Medical Center, Kamogawa-City, Japan.
AJNR. American Journal of Neuroradiology
|November 1, 1996
Summary
Magnetic resonance imaging (MRI) reveals key indicators of corticobasal degeneration. These include atrophy in specific brain regions and signal changes in the putamen, aiding diagnosis.
Area of Science:
- Neurology
- Radiology
- Pathology
Background:
- Corticobasal degeneration (CBD) is a rare, progressive neurodegenerative disorder.
- Accurate diagnosis of CBD is challenging, often requiring correlation with neuropathology.
Purpose of the Study:
- To illustrate the characteristic magnetic resonance (MR) imaging findings in corticobasal degeneration.
- To compare MR imaging findings with corresponding pathologic specimens to validate diagnostic accuracy.
Main Methods:
- Retrospective review of MR imaging studies in patients with clinically diagnosed corticobasal degeneration.
- Correlation of MR imaging findings with autopsy-confirmed neuropathologic data.
Main Results:
- MR imaging demonstrated characteristic patterns of atrophy, notably in the perirolandic gyri.
- Atrophy of the basal ganglia and T2-weighted signal prolongation in the posterolateral putamen were consistently observed.
- These MR findings showed strong correlation with the neuropathologic hallmarks of corticobasal degeneration.
Conclusions:
- Specific MR imaging findings, including perirolandic and basal ganglia atrophy and putaminal T2 prolongation, are highly suggestive of corticobasal degeneration.
- MR imaging serves as a valuable tool in supporting the clinical diagnosis of corticobasal degeneration prior to definitive pathologic confirmation.