Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ISCOMs (immunostimulating complexes): the first decade

I G Barr1, G F Mitchell

  • 1CSL Limited, Parkville, Victoria, Australia.

Immunology and Cell Biology
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces.

Journal of the American Heart Association·2018
Same author

Interrelationships between obesity, obstructive sleep apnea syndrome and cardiovascular risk in obese adolescents.

International journal of obesity (2005)·2015
Same author

Influenza gain-of-function experiments: their role in vaccine virus recommendation and pandemic preparedness.

mBio·2014
Same author

Antibody landscapes after influenza virus infection or vaccination.

Science (New York, N.Y.)·2014
Same author

Hybridoma antibodies in immunodiagnosis of parasitic infection.

Immunology today·2014
Same author

Host-protective immunity and its suppression in a parasitic disease: murine cutaneous leishmaniasis.

Immunology today·2014
Same journal

Multi-Omics Comes of Age: Immune Profiling of Human Aging.

Immunology and cell biology·2026
Same journal

Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment.

Immunology and cell biology·2026
Same journal

Ancestry Matters in Decoding Immunity.

Immunology and cell biology·2026
Same journal

Improving COVID-19 Vaccine Uptake Among Ethnic Minority Communities in Wales: A Community-Based Approach.

Immunology and cell biology·2026
Same journal

4-1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions.

Immunology and cell biology·2026
Same journal

Highlights of 2025: Advances in the T-Cell Regulation of Germinal Center Response.

Immunology and cell biology·2026
See all related articles

Immunostimulating complexes (ISCOMs) are a promising vaccine technology. Clinical trials are beginning to assess their potential as potent adjuvants for human vaccines against diseases like AIDS, malaria, and influenza.

Area of Science:

  • Immunology and Vaccine Development
  • Biotechnology and Nanotechnology

Background:

  • Novel immunostimulating complexes (ISCOMs) emerged over a decade ago.
  • There is a critical need for advanced vaccine adjuvants beyond traditional aluminum salts, especially for subunit vaccines.
  • Current vaccine research targets diseases such as AIDS, malaria, and influenza.

Purpose of the Study:

  • To review the progress and current standing of ISCOM technology in vaccine research and medicine.
  • To evaluate the potential of ISCOMs as potent adjuvants for human vaccines.

Main Methods:

  • Review of scientific literature and research on ISCOM technology.
  • Analysis of ISCOM composition: saponin, cholesterol, phospholipid, and protein.
  • Examination of ISCOMs' role in promoting specific immune responses.

Related Experiment Videos

Main Results:

  • ISCOM technology has primarily advanced within vaccine research.
  • ISCOMs are submicron, non-living particles with potential as effective vaccine adjuvants.
  • Clinical trials are initiating to validate ISCOMs for human vaccine applications.

Conclusions:

  • ISCOMs represent a significant advancement in adjuvant technology.
  • The technology is entering a crucial phase with clinical trials to determine efficacy in human vaccines.
  • ISCOMs show promise for enhancing immunogenicity in modern subunit vaccines.