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The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system
1Biomedical Sciences Division, King's College London, UK.
The Journal of Pharmacy and Pharmacology
|February 1, 1996
Abstract:
The presence of the blood-brain barrier (BBB), reduces the brain uptake of many drugs, peptides and other solutes from blood. Strategies for increasing the uptake of drugs and peptide-based drugs include; structural modifications to increase plasma half-life; improving passive penetration of the BBB by increasing the lipophilicity of the molecule; designing drugs which react with transporters present in the BBB; and reducing turnover and efflux from the central nervous system (CNS).