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Direct Detection of the Acetate-forming Activity of the Enzyme Acetate Kinase
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Published on: December 19, 2011

Identification, cloning and sequencing the aceA gene involved in acetan biosynthesis in Acetobacter xylinum

A M Griffin1, V J Morris, M J Gasson

  • 1Institute of Food Research, Norwich Laboratory, Colney, UK. annette.griffin/b

FEMS Microbiology Letters
|March 15, 1996
PubMed

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Phase II Reactions: Acetylation Reactions01:24

Phase II Reactions: Acetylation Reactions

Acetylation, a phase II biotransformation reaction, introduces an acetyl group to drugs or their metabolites. Acetyltransferase enzymes facilitate this reaction, which resembles α-amino acid conjugation due to the addition of a functional group to the drug molecule.
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...