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Related Experiment Videos

F wave studies after intrathecal methotrexate administration

H Grzelec1, C Fryze, P Nowacki

  • 1Department of Neurology, Medical School, Szczecin, Poland.

Acta Neurologica Scandinavica
|October 1, 1996
PubMed
Summary

Intrathecal methotrexate (ITMTX) chemotherapy, used to prevent central nervous system involvement in lymphoma patients, did not cause immediate changes in nerve conduction or motor neuron function. This study assessed electrophysiological parameters before and after ITMTX administration.

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Area of Science:

  • Neuroscience
  • Oncology
  • Pharmacology

Background:

  • High-grade non-Hodgkin's lymphomas require chemotherapy, including intrathecal administration to prevent central nervous system (CNS) involvement.
  • Intrathecal methotrexate (ITMTX) is a common agent used for CNS prophylaxis.
  • Potential neurotoxicity of ITMTX necessitates careful monitoring of neurological function.

Purpose of the Study:

  • To evaluate the immediate effects of single-dose intrathecal methotrexate (ITMTX) and prednisolone on peripheral nerve and motor neuron function.
  • To assess changes in nerve conduction velocity, F-wave parameters, and motor neuron excitability following ITMTX administration in lymphoma patients.

Main Methods:

  • Electrophysiological examinations were performed on 20 high-grade non-Hodgkin's lymphoma patients (aged 40-71).

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  • Studies included conventional nerve conduction (velocity, amplitude), F-wave latency/amplitude, and F ratio measurements for peroneal and tibial nerves.
  • Examinations were conducted before and 24 hours after the first intrathecal methotrexate (ITMTX) and prednisolone injection.

    • Main Results:

    • No statistically significant differences were observed in peripheral nerve conduction parameters (velocity, amplitude) before and after ITMTX administration.
    • F-wave latency, amplitude, and F ratio measurements showed no significant changes.
    • Proximal, paraspinal motor conduction, and motor neuron excitability remained unaltered after a single ITMTX dose.

    Conclusions:

    • Single administration of intrathecal methotrexate (ITMTX) and prednisolone does not appear to cause acute alterations in peripheral nerve conduction or motor neuron excitability.
    • Electrophysiological monitoring did not reveal immediate neurotoxic effects of ITMTX in this patient cohort.
    • Further studies are warranted to assess long-term neurophysiological effects of ITMTX in lymphoma treatment.