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Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
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Related Experiment Video

Updated: Jul 17, 2026

Measuring Peptide Translocation into Large Unilamellar Vesicles

Measuring Peptide Translocation into Large Unilamellar Vesicles

Published on: January 27, 2012

Peptide transporters

V Ganapathy¹, F H Leibach

¹Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912-2100, USA.

Current Opinion in Nephrology and Hypertension

|September 1, 1996

Summary

Proton-coupled peptide transporters in animal cells are unique due to their energy use and broad substrate acceptance. These transporters are vital for protein nutrition in the small intestine and kidney, with other important physiological roles.

Area of Science:

Biochemistry
Cell Biology
Physiology

Background:

Proton-coupled peptide transporters are crucial in animal cells.
They exhibit unique energetics and accept diverse peptide substrates.
Abundant expression in the small intestine and kidney highlights their role in protein nutrition.

Purpose of the Study:

To explore the unique characteristics of proton-coupled peptide transporters.
To investigate their significance in protein nutrition and other physiological functions.

Main Methods:

Analysis of transporter energetics.
Substrate specificity studies.
Expression pattern analysis in key organs.

Main Results:

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Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

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Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide

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Last Updated: Jul 17, 2026

Measuring Peptide Translocation into Large Unilamellar Vesicles

Measuring Peptide Translocation into Large Unilamellar Vesicles

Published on: January 27, 2012

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Published on: December 16, 2016

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide

Published on: December 19, 2020

Demonstrated unique energy coupling mechanisms in peptide transport.
Confirmed broad substrate acceptance for chemically diverse peptides.
Highlighted significant expression in the small intestine and kidney.

Conclusions:

Proton-coupled peptide transporters play a critical role in protein nutrition.
These transporters have broader physiological, pharmacological, and clinical relevance beyond nutrient absorption.