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Related Experiment Videos

Changes in splenic volume after partial splenic embolization in children

Y Watanabe1, T Todani, T Noda

  • 1Department of Pediatric Surgery, Kagawa Medical School, Japan.

Journal of Pediatric Surgery
|February 1, 1996
PubMed
Summary

Partial splenic embolization (PSE) in children with splenomegaly leads to initial splenic volume increase, followed by a decrease as infarcted tissue is absorbed. Splenic volume stabilizes, often remaining enlarged but achieving therapeutic platelet counts.

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Area of Science:

  • Pediatric Interventional Radiology
  • Hepatobiliary Surgery
  • Pediatric Hematology

Background:

  • Splenomegaly is a common cause of thrombocytopenia in children.
  • Partial splenic embolization (PSE) is a treatment option for hypersplenism.
  • Assessing changes in splenic volume post-PSE is crucial for understanding treatment efficacy.

Observation:

  • Five children (ages 1-14) with hypersplenism underwent PSE.
  • Computed tomography (CT) scans measured splenic volume before and after PSE.
  • Follow-up ranged from 1 month to over 8 years.

Findings:

  • Within 2 weeks, splenic volume increased 110%-140% of pre-PSE levels.
  • Infarcted splenic tissue resolved by 3-4 months, causing significant volume reduction.

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  • Splenic volume stabilized post-resolution, remaining enlarged (2-7x standard) but correlating with normalized platelet counts.

    • Implications:

    • The initial 4 weeks post-PSE carry risks for splenic capsule complications.
    • Significant splenic infarction (>80%) may preclude the need for re-embolization.
    • Long-term splenic volume reduction post-PSE is achievable, offering sustained therapeutic benefits for thrombocytopenia.