Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inhibitory glutamate receptor channels

T A Cleland1

  • 1Biology Department 0357, UCSD, La Jolla 92093-0357, USA.

Molecular Neurobiology
|October 1, 1996
PubMed
Summary

Inhibitory glutamate receptors (IGluRs) are ion channels found in invertebrates that resemble GABA receptors but are genetically similar to glycine receptors. Their unique properties explain avermectin

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imprinted Rasgrf1 expression in neonatal mice affects olfactory learning and memory.

Genes, brain, and behavior·2011
Same author

Characterization of the synaptic properties of olfactory bulb projections.

Chemical senses·2004
Same author

How spike synchronization among olfactory neurons can contribute to sensory discrimination.

Journal of computational neuroscience·2001
Same author

Concentration tuning mediated by spare receptor capacity in olfactory sensory neurons: A theoretical study.

Neural computation·1999
Same author

Characterizing complex chemosensors: information-theoretic analysis of olfactory systems.

Trends in neurosciences·1999
Same author

Inhibitory glutamate receptor channels in cultured lobster stomatogastric neurons.

Journal of neurophysiology·1998

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Inhibitory glutamate receptors (IGluRs) are ion channel proteins related to glycine and GABA receptors.
  • IGluRs are gated by glutamate and permeable to chloride and potassium ions.
  • They exhibit physiological and pharmacological similarities to GABA receptors but sequence similarities to glycine receptors.

Purpose of the Study:

  • To investigate the characteristics and functions of IGluRs.
  • To explore the potential role of IGluRs in the action of avermectins.
  • To examine IGluRs as a model system for studying adaptive molecular evolution.

Main Methods:

  • Analysis of amino acid sequences of cloned IGluRs.
  • Pharmacological characterization using agonists like ibotenic acid and quisqualate.
  • Investigation of avermectin effects on IGluRs at various concentrations.

Main Results:

  • Cloned IGluRs show highest sequence similarity to glycine receptors.
  • Ibotenic acid activates all IGluRs; quisqualate is a limited agonist.
  • Avermectins modulate IGluRs, potentially explaining their selective toxicity.
  • IGluRs are found in protostomes and pseudocoelomates, mediating inhibition in neurons and muscles.

Conclusions:

  • IGluRs represent a distinct class of receptors with unique pharmacological profiles.
  • Their presence and function in invertebrates may explain avermectin efficacy and safety.
  • Protostome IGluRs offer a diverse system for studying receptor evolution and adaptation.

Related Experiment Videos