Related Experiment Videos
Low-dose perioperative 5-fluorouracil in trabeculectomy
1Department of Ophthalmology, University Hospital, Nottingham, United Kingdom.
Ophthalmic Surgery and Lasers
|November 1, 1996
Summary
Perioperative application of 5-fluorouracil (5-FU) in trabeculectomy is safe and effective for patients not at high risk of failure. This approach demonstrated good intraocular pressure control with few complications.
Area of Science:
- Ophthalmology
- Glaucoma Surgery
- Pharmacology
Background:
- 5-Fluorouracil (5-FU) is used post-trabeculectomy for high-risk cases via subconjunctival injections.
- Laboratory evidence suggests perioperative 5-FU exposure may be beneficial.
Purpose of the Study:
- To investigate the outcome of perioperative 5-FU application in trabeculectomy.
- To assess the safety and efficacy of this novel administration route.
Main Methods:
- Retrospective review of 23 eyes from 21 patients undergoing trabeculectomy.
- Perioperative application of low-dose (25 mg/ml) 5-FU.
- Minimum follow-up of 1 year.
Main Results:
- At 1 year, 65% of eyes achieved intraocular pressure (IOP) < 21 mm Hg without medication.
- 13% achieved target IOP with fewer or same medications.
- Successful outcomes correlated with shorter disease duration and fewer indications for antimetabolite use.
- Few 5-FU related complications were observed.
Conclusions:
- Perioperative 5-FU administration in trabeculectomy is safe and effective.
- This method is suitable for patients not at high risk of surgical failure.
- Further research may explore its broader application in glaucoma management.