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Interacting signaling pathways controlling multicellular development in Dictyostelium

R A Firtel1

  • 1Department of Biology, Center for Molecular Genetics, University of California at San Diego, La Jolla 92093-0634, USA. rafirtel@ucsd.edu

Current Opinion in Genetics & Development
|October 1, 1996
PubMed
Summary

Cyclic adenosine monophosphate (cAMP) controls Dictyostelium development through distinct signaling pathways. Different concentrations of extracellular cAMP regulate aggregation and multicellular differentiation, involving novel transcription factors and kinases.

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Area of Science:

  • Cellular and Molecular Biology
  • Developmental Biology
  • Biochemistry

Background:

  • Extracellular cyclic adenosine monophosphate (cAMP) is a crucial signaling molecule in Dictyostelium discoideum development.
  • cAMP mediates processes like aggregation and multicellular differentiation through specific receptors.
  • Two distinct signaling mechanisms are involved: one for aggregation and another for differentiation.

Purpose of the Study:

  • To review the mechanisms by which extracellular cAMP differentially regulates Dictyostelium aggregation and multicellular differentiation.
  • To summarize recent findings on pathways controlling cell-type differentiation, including key kinases and transcription factors.

Main Methods:

  • Literature review of studies on Dictyostelium development and cAMP signaling.

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  • Analysis of receptor-mediated signaling pathways.
  • Discussion of molecular regulators of cell-type differentiation.

    • Main Results:

    • Low nanomolar pulses of cAMP control aggregation via G-protein-coupled receptors.
    • Continuous micromolar cAMP signals activate a non-G-protein-coupled pathway for differentiation.
    • Glycogen synthase kinase 3 and cAMP-dependent protein kinase are key regulators of cell-type differentiation.

    Conclusions:

    • Extracellular cAMP employs distinct concentration-dependent pathways to control Dictyostelium development.
    • Signaling cascades involving specific kinases and transcription factors are critical for cell-type regulation.
    • Understanding these pathways provides insights into developmental processes in both Dictyostelium and metazoans.