Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell cycle checkpoints: preventing an identity crisis

S J Elledge1

  • 1Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Science (New York, N.Y.)
|December 6, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Some Like It Sweet: Dendritic Cells Add Sugar to Their T(ea).

Cell·2020
Same author

Dissecting cancer pathways and vulnerabilities with RNAi.

Cold Spring Harbor symposia on quantitative biology·2006
Same author

Sensing and signaling DNA damage: roles of Rad17 and Rad9 complexes in the cellular response to DNA damage.

Harvey lectures·2003
Same author

The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway.

Cold Spring Harbor symposia on quantitative biology·2003
Same author

Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints.

Cell·2001
Same author

ATR and ATRIP: partners in checkpoint signaling.

Science (New York, N.Y.)·2001
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
See all related articles

Cell cycle checkpoints ensure DNA replication and chromosome segregation accuracy. Loss of these checkpoints leads to genomic instability and cancer, highlighting their critical role in cell health.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Cell cycle checkpoints are crucial for maintaining genomic stability.
  • These pathways regulate cell cycle transitions and respond to DNA damage.
  • Checkpoint failure is linked to cancer development.

Purpose of the Study:

  • To elucidate the mechanisms of cell cycle checkpoint control.
  • To understand how checkpoints respond to DNA damage and replication stress.
  • To highlight the conserved nature of these pathways across eukaryotes.

Main Methods:

  • Review of recent advances in signal transduction pathways.
  • Analysis of checkpoint components in response to DNA damage, replication blocks, and spindle damage.
  • Comparative analysis of eukaryotic cell cycle regulatory machinery.

Related Experiment Videos

Main Results:

  • Identification of signal transduction pathways transmitting checkpoint signals.
  • Demonstration of checkpoint roles in DNA repair and cell cycle arrest.
  • Evidence for conserved checkpoint components across eukaryotes.

Conclusions:

  • Cell cycle checkpoints are essential for high-fidelity cell division.
  • Checkpoint dysfunction contributes to genomic instability and oncogenesis.
  • The conserved nature of checkpoint pathways offers insights into fundamental cell biology.