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Incongruent follicular development reduces gamete intrafallopian transfer pregnancy rate
L Rombauts1, D Webster, C E Wood
1Monash IVF, Epworth Hospital, Richmond, Victoria, Australia.
Objective:
To test the null hypothesis that asymmetric or incongruent follicular development does not influence GIFT pregnancy rates (PRs).
Design:
A prospective comparative study.
Setting:
Tertiary referral center for infertility.
Patient(S):
Ninety-three consecutive infertile patients having GIFT.
Intervention(S):
Controlled ovarian hyperstimulation and GIFT.
Main Outcome Measure(S):
The incongruity ratio as a parameter of the asymmetry in follicular development and the clinical PR.
Result(S):
An inverse relationship was observed between the degree of incongruity and the clinical PRs. In patients with an incongruity ratio < 1.5, the clinical PR was 56.1%. In patients with an incongruity ratio > or = 1.5, the clinical PR was only 17.3%.
Conclusion(S):
Incongruent follicular development during controlled ovarian hyperstimulation has a marked negative influence on the outcome of GIFT cycles. Factors such as side of the gamete transfer and oocyte quality did not account for the observed differences.