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Neurogenic inflammation and tooth pulp innervation pattern in sympathectomized rats
R C Komorowski1, C D Torneck, J W Hu
1University of Toronto, Faculty of Dentistry, Ontario, Canada.
Journal of Endodontics
|August 1, 1996
Summary
This study reveals collateral C-fiber innervation between rat molar pulps. Neurogenic inflammation (NI) patterns suggest nerve fibers connect adjacent teeth within the same dental quadrant.
Area of Science:
- Neuroscience
- Dental Research
- Pain Research
Background:
- C-fiber innervation plays a role in neurogenic inflammation (NI).
- Understanding collateral innervation in molar pulps is crucial for pain pathways.
Purpose of the Study:
- To investigate potential collateral C-fiber innervation between rat molar pulps.
- To assess the role of sympathetic efferents in mustard oil (MO)-induced NI.
Main Methods:
- Mustard oil (MO) applied to first molar pulp in guanethidine sympathectomized and unsympathectomized rats.
- Saline control group used for comparison.
- Plasma extravasation measured using Evans' Blue (EB) dye spectrophotometry to infer NI patterns.
Main Results:
- Significant differences in EB ratios observed in molars between guanethidine sympathectomized and control groups, indicating collateral innervation.
- No significant difference in EB ratios between sympathectomized and unsympathectomized groups, suggesting minimal sympathetic influence on MO-induced NI.
Conclusions:
- Evidence supports collateral C-fiber innervation within rat molar pulps in the same dental quadrant.
- Sympathetic efferents do not significantly affect the degree of MO-induced NI in this model.