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[Isoenzymes of creatine kinase in the perinatal period (author's transl)]
Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Fur Klinische Chemie Und Klinische Biochemie
|June 1, 1977
Insights
Newborns have higher creatine kinase (CK) levels than adults, normalizing within 10 days. CK isoenzymes (MM, MB, BB) are present in newborns and mothers, impacting diagnostic analysis.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Pediatric Medicine
Context:
- Serum creatine kinase (CK) levels vary significantly between newborns and adults.
- Specific CK isoenzymes (MM, MB, BB) are detected in neonatal and maternal samples.
Purpose:
- To investigate the developmental changes in serum creatine kinase (CK) catalytic concentration in newborns.
- To identify the presence and significance of different CK isoenzymes in neonatal serum.
Summary:
- Newborn serum exhibits elevated creatine kinase (CK) catalytic activity compared to adults.
- These elevated CK levels in neonates decrease to adult ranges within the first 10 days of life.
- The study detected MM-, MB-, and BB-isoenzymes of CK in the serum of women in labor, cord blood, and newborns.
Impact:
- Highlights the importance of considering neonatal physiological differences in CK levels for accurate clinical interpretation.
- Suggests that the presence of multiple CK isoenzymes in newborns may influence diagnostic strategies.
- Provides crucial data for the interpretation of creatine kinase isoenzyme analyses in pediatric and obstetric settings.
Abstract:
The serum of new-born children shows a higher catalytic concentration of creatine kinase than adult serum. These values reach normal adult levels within the first 10 days of life. In addition to the MM-, the MB- and BB-isoenzymes of creatine kinase are also found in the serum of women in labour, in cord-serum, and in the serum of newborn children. These findings should be taken into consideration in the analysis of creatine kinase isoenzymes.