Monsel's solution-induced artifact in the uterine cervix

Area of Science:

• Gynecologic Pathology
• Surgical Pathology
• Histopathology

Background:

• Monsel's solution is commonly used for hemostasis after cervical biopsies.
• Potential artifacts induced by Monsel's solution can impact histopathological interpretation.

Purpose of the Study:

• To document and quantify Monsel's solution-related artifacts in cervical cone biopsy specimens.
• To correlate the degree of artifact with the timing of Monsel's solution use.

Main Methods:

• Review of 24 cervical loop electrosurgical cone biopsy specimens over a 3-month period.
• Evaluation for necrosis artifact of the surface epithelium.
• Quantification of artifact degree and correlation with antecedent Monsel's solution use.

Main Results:

• Definite changes were observed in 3 of 8 specimens within 10 days of Monsel's solution use.
• Four of 8 specimens showed changes between 10 and 18 days post-application.
• No significant changes were noted in specimens obtained after 18 days.

Conclusions:

• Routine use of Monsel's solution can interfere with disease recognition in cone biopsy specimens.
• Biopsies performed within 3 weeks of Monsel's solution application may show artifacts.
• Careful consideration of the timing between Monsel's solution application and cone biopsy is recommended.