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Hepatitis G virus infection in patients with hepatitis C virus infection undergoing liver transplantation
M Berenguer1, N A Terrault, M Piatak
1Department of Medicine, Department of Veterans Affairs Medical Center, San Francisco, California, USA.
Insights
Hepatitis G virus (HGV) coinfection is common in liver transplant patients with hepatitis C virus (HCV). However, HGV coinfection does not impact liver disease severity or survival post-transplantation.
Area of Science:
- Hepatology
- Virology
- Transplantation Medicine
Background:
- Hepatitis G virus (HGV) transmission via blood transfusion is known, but its impact on chronic liver disease remains unclear.
- The study investigates the role of HGV in patients with hepatitis C virus (HCV) undergoing liver transplantation.
Purpose of the Study:
- Determine HGV prevalence in HCV patients awaiting liver transplantation.
- Evaluate the effect of HGV coinfection on post-transplantation HCV outcomes.
Main Methods:
- Serum samples from 124 HCV patients undergoing liver transplantation were analyzed for HCV and HGV RNA.
- HCV RNA levels were quantified using branched DNA assay, and HCV genotyping was performed.
Main Results:
- Prevalence of HGV infection was 24% before and 28% after transplantation.
- HGV coinfection did not significantly alter post-transplantation HCV RNA levels or disease severity.
- HCV genotype 1b was more common in coinfected patients, but graft and patient survival were unaffected.
Conclusions:
- HGV coinfection is frequent in end-stage HCV patients undergoing liver transplantation.
- No association found between HGV coinfection and post-transplantation liver disease severity, graft, or patient survival.
Background & Aims:
Hepatitis G virus (HGV) is transmissible by blood transfusion, but its role in chronic liver disease is unknown. The aim of this study was to determine the prevalence of HGV infection in patients infected with hepatitis C virus (HCV) undergoing transplantation and evaluate the effects of HGV coinfection on the course of posttransplantation HCV infection.
Methods:
One hundred twenty-four patients infected with HCV undergoing liver transplantation were studied. Serum samples were tested for HCV and HGV RNA; HCV RNA was quantitated by branched DNA assay, and HCV genotype was determined.
Results:
The prevalence of pretransplantation and posttransplantation HGV infection was 24% and 28%, respectively. Pre-transplantation HGV infection was positively correlated with posttransplantation HGV infection (P < 0.001). Pretransplantation clinical features were not different in patients infected with HCV with and without HGV infection. Posttransplantation HCV RNA levels were not significantly different in patients with and without HGV coinfection, but HCV genotype 1b was more frequent in patients with HGV coinfection. There were no differences in the histological severity of posttransplantation liver disease, graft, and patient survival between patients with and without HGV infection.
Conclusions:
Although HGV coinfection is frequent in patients with end-stage HCV disease undergoing liver transplantation, there is no association between the presence of HGV coinfection and the severity of liver disease post-transplantation, graft, or patient survival.
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