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Progressive pressure expansion in skeletal muscle ventricle conditioning
K J Gustafson1, J D Sweeney, J Gibney
1Bioengineering Program, Arizona State University, Tempe 85287-6006, USA.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|September 1, 1996
Summary
Progressive pressure expansion of skeletal muscle ventricles (SMVs) improved their pumping performance. This conditioning method, using a compliant pneumatic implant, enhanced SMV volume and stroke volume compared to controls.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Skeletal Muscle Physiology
Background:
- Skeletal muscle ventricle (SMV) conditioning often leads to decreased muscle performance.
- Optimizing SMV function is crucial for potential cardiac assist applications.
Purpose of the Study:
- To investigate the impact of progressive resting pressure expansion and dynamic training on SMV pumping capability.
- To evaluate the adaptation of SMVs under controlled pressure loading.
Main Methods:
- SMVs were created from goat latissimus dorsi muscle.
- Experimental SMVs underwent progressive pressure expansion (40 to 100-120 mmHg over 8 weeks) using a compliant pneumatic implant.
- Control SMVs were conditioned with a non-expanded implant; both groups received electrical stimulation.
Main Results:
- Experimental SMVs demonstrated increased volume and adapted pressure-volume curves.
- Two of three experimental SMVs exhibited superior stroke volumes compared to controls across various conditions.
- Progressive pressure expansion positively influenced SMV pumping performance.
Conclusions:
- Progressive pressure expansion via a compliant implant system enhances SMV pumping performance.
- This conditioning strategy shows promise for improving SMV function for cardiac applications.
- Further research is warranted to explore the full potential of this technique.
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