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Transluminal aortic valve placement. A feasibility study with a newly designed collapsible aortic valve
N Moazami1, M Bessler, M Argenziano
1Department of Surgery, Columbia-Presbyterian Medical Center, New York, New York 10032, USA.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|September 1, 1996
Summary
A novel collapsible bioprosthetic aortic valve was developed for catheter-based delivery. This stent valve demonstrated acceptable hemodynamics and feasibility in animal models, though long-term durability requires further study.
Area of Science:
- Biomedical Engineering
- Cardiovascular Devices
- Prosthetic Valves
Background:
- Percutaneous stents are utilized in vascular repair, including abdominal aneurysm repair.
- Existing methods for aortic valve replacement can be invasive.
Purpose of the Study:
- To design and evaluate a collapsible bioprosthetic aortic valve for transluminal catheter placement.
- To assess the hemodynamic performance and in-vivo feasibility of this novel stent valve.
Main Methods:
- A trileaflet stent valve constructed from stainless steel and bovine pericardium was tested in a pulse duplicator.
- Hemodynamic parameters including transvalvular gradient and regurgitation were measured.
- The stent valve was implanted in a porcine model using a 24 Fr catheter for transluminal delivery.
Main Results:
- The stent valve generated normal systemic aortic pressure with a mean gradient of 14.9 +/- 7 mmHg in the pulse duplicator.
- Regurgitation fraction ranged from 10-18% in the optimal ring size.
- Two of three animal implants were successful, demonstrating good valve function and secure anchoring post-procedure, while one experienced structural failure and dislodgement.
Conclusions:
- Development of a hemodynamically acceptable prosthetic aortic valve for transluminal placement is feasible.
- The stent valve shows promise for minimally invasive aortic valve replacement.
- Further investigation into long-term survival and structural integrity is warranted.