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Increased nailfold capillary dimensions in primary Raynaud's phenomenon and systemic sclerosis
M Bukhari1, A L Herrick, T Moore
1University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford.
British Journal of Rheumatology
|November 1, 1996
Summary
Primary Raynaud's phenomenon (PRP) and systemic sclerosis (SSc) show increased nailfold capillary dimensions. While SSc also has reduced capillary density, PRP may not be entirely benign, indicating underlying vascular changes.
Area of Science:
- Vascular Biology
- Rheumatology
- Dermatology
Background:
- Primary Raynaud's phenomenon (PRP) and systemic sclerosis (SSc) are conditions affecting small blood vessels.
- Nailfold capillaroscopy is a non-invasive method to assess microvascular changes.
- Understanding structural vascular alterations is crucial for disease management.
Purpose of the Study:
- To compare nailfold capillary dimensions and density in patients with PRP and SSc against healthy controls.
- To investigate the extent of microvascular changes in PRP and SSc.
Main Methods:
- Nailfold capillary dimensions and density were measured using capillaroscopy.
- The study included 10 controls, 9 patients with PRP, and 10 patients with SSc.
Main Results:
- Both PRP and SSc groups exhibited significantly increased capillary dimensions compared to controls (P < 0.01).
- Systemic sclerosis patients showed the most pronounced dimensional increases (SSc vs. PRP, P < 0.05).
- Capillary density was significantly reduced in the SSc group versus controls (P = 0.004).
Conclusions:
- Structural vascular changes are present in both PRP and SSc.
- The findings suggest that PRP may involve more than just functional vasospasm, indicating potential structural pathology.
- These microvascular alterations in PRP warrant further investigation and may impact long-term prognosis.