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Analysis of a theoretical model based on similarity for studying RNA base pairings
P Di Gennaro1, G Sello, M Termini
1Dipartimento di Genetica e Biologia dei Microrganismi, Universita' degli Studi, Milano, Italy.
Journal of Theoretical Biology
|August 21, 1996
Abstract:
A theoretical model for studying RNA base pairing is presented, based on similarity measures of the bases and corresponding indexes. Similarity calculations are made by evaluating atomic importance in molecules, a method that uses an original method for the calculation of electronic energy. The application of the model to both Watson-Crick and non-Watson-Crick pairings is commented on. Some theoretical considerations concerning the capability of the genetic code to repair dangerous mutations contribute to the ongoing debate.