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Effects of 8-OH-DPAT, a 5-HT1A receptor agonist, and DOI, a 5-HT2A/2C agonist, on monosynaptic transmission in
1Department of Pharmacy, Branch Hospital, Faculty of Medicine, University of Tokyo, Japan. myutaka@hongo.ecc.u-tokyo.ac.jp
Abstract:
We investigated the effect of 5-HT1A receptor agonist (-/+)-8-hydroxy-2-(di-N-propylamino)tetraline (8-OH-DPAT) and the 5-HT2A/2C receptor agonist (-/+)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on monosynaptic transmission in spinalized rats. 8-OH-DPAT significantly inhibited the excitation of alpha-motoneurons evoked by monosynaptic transmission without a direct effect on alpha-motoneuron excitation. DOI potentiated the excitation of alpha-motoneurons by both direct stimulation and monosynaptic transmission. These results indicate that activation of 5-HT1A receptors inhibits monosynaptic transmission, whereas activation of 5-HT2A/2C receptors enhances it.