Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vinblastine toxicity to the ocular surface

I Chowers1, J Frucht-Pery, C S Siganos

  • 1Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.

Anti-Cancer Drugs
|September 1, 1996
PubMed
Summary

Accidental ocular exposure to vinblastine can cause severe eye damage, including dry eyes and corneal scarring. Steroid treatment did not appear to improve outcomes in a rabbit model.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A hypothetical intervention on the use of hearing aids for the risk of dementia in people with hearing loss in UK Biobank.

American journal of epidemiology·2024
Same author

Daytime Sleepiness, Apnea, Neuroimaging Correlates and Cortisol Dysregulation in a Memory Clinic Cohort.

The journal of prevention of Alzheimer's disease·2024
Same author

Evaluation of Clinical Meaningfulness of Fortasyn Connect in Terms of "Time Saved".

The journal of prevention of Alzheimer's disease·2024
Same author

Thermally stable Peltier controlled vacuum chamber for electrical transport measurements.

The Review of scientific instruments·2024
Same author

Validation, Deployment, and Real-World Implementation of a Modular Toolbox for Alzheimer's Disease Detection and Dementia Risk Reduction: The AD-RIDDLE Project.

The journal of prevention of Alzheimer's disease·2024
Same author

Multimodal Precision Prevention - A New Direction in Alzheimer's Disease.

The journal of prevention of Alzheimer's disease·2023

Area of Science:

  • Ophthalmology
  • Toxicology
  • Drug Safety

Background:

  • Antineoplastic drugs are used in ophthalmology, but can cause ocular side effects.
  • Accidental exposure to these drugs can lead to significant eye injury.

Observation:

  • A case of accidental ocular trauma by vinblastine resulted in acute keratopathy, decreased visual acuity, dry eyes, and corneal scarring.
  • Animal studies using vinblastine instillation showed acute conjunctivitis and keratopathy, mirroring human patient outcomes.

Findings:

  • Vinblastine ocular exposure can lead to severe keratopathy and dry eye syndrome.
  • Local steroid treatment showed no significant benefit in mitigating vinblastine-induced ocular damage in rabbits.

Implications:

Related Experiment Videos

  • Understanding the ocular toxicity of antineoplastic agents like vinblastine is crucial for patient safety.
  • Further research into the mechanisms of dry eye induction and potential treatments is warranted.