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Correlation between human vascular smooth muscle cell proliferation and protein kinase C alpha-expression: effect of
D Marilley1, G Mosieniak, D Boscoboinik
1Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland.
Biochemistry and Molecular Biology International
|November 1, 1996
Abstract:
Population doublings of four different human aortic vascular smooth muscle cell strains correlate with the amount of protein kinase C alpha present in these cells. d-alpha-Tocopherol inhibits, at different extents, protein kinase C activity in all cells studied. Furthermore, the extent of inhibition positively correlates with amount of protein kinase C alpha expression and not with that of the other isoforms. It is suggested that, in human aortic smooth muscle cells, protein kinase C alpha modulates cell proliferation and serves as a target for d-alpha-tocopherol inhibition.