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Related Experiment Videos

Growth hormone-releasing peptides: clinical and basic aspects

J Argente1, L M García-Segura, J Pozo

  • 1Department of Pediatrics, Universidad Autónoma, Madrid, Spain.

Hormone Research
|January 1, 1996
PubMed
Summary

Growth hormone (GH)-releasing peptides (GHRPs) are orally active and stimulate GH secretion in children. GHRP-6 treatment modulated hypothalamic neurons involved in GH regulation in rats.

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Area of Science:

  • Endocrinology
  • Neuroscience

Background:

  • Growth hormone (GH)-releasing peptides (GHRPs) are synthetic peptides that stimulate GH release.
  • GHRPs act on the pituitary via a distinct receptor and have hypothalamic binding sites.
  • The precise hypothalamic and pituitary mechanisms of GHRP action remain unclear.

Purpose of the Study:

  • To investigate the oral activity of GHRP-2 on GH release in normal children.
  • To analyze GHRP-2 response in obese adolescents and compare it with GHRH effects.
  • To examine GHRP-6 effects on hypothalamic GH-releasing hormone (GHRH) and somatostatin (SS) neurons in rats.

Main Methods:

  • Oral administration of GHRP-2 in normal children and obese adolescents.
  • Intravenous administration of GHRH alone and in combination with GHRP-2.

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  • Continuous treatment with GHRP-6 in female dwarf rats followed by in situ hybridization for GHRH and SS mRNA.

    • Main Results:

    • Orally administered GHRP-2 stimulated GH secretion in normal children, with synergistic effects when combined with GHRH.
    • Obese adolescents showed a greater response to GHRP-2 compared to normal controls.
    • GHRP-6 treatment increased GHRH mRNA in the posterior arcuate nucleus and decreased SS mRNA in the posterior periventricular nucleus of rats.

    Conclusions:

    • GHRP-2 is orally effective in stimulating GH secretion in children, with enhanced response in obese individuals.
    • GHRP-6 modulates hypothalamic GHRH and SS neurons, suggesting a role in regulating GH secretion.
    • Further research is needed to elucidate the direct mechanisms of GHRP action at hypothalamic and pituitary levels.