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Naproxen sodium

L B Sutton1

  • 1Glaxo Wellcome Inc., Research Triangle Park, N.C. USA.

Journal of the American Pharmaceutical Association (Washington, D.C. : 1996)
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Naproxen sodium offers pain relief and reduces fever and inflammation. However, it carries risks such as gastrointestinal issues and is not suitable for individuals with certain health conditions like heart failure.

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Area of Science:

  • Pharmacology
  • Internal Medicine

Background:

  • Naproxen sodium is a widely used nonsteroidal anti-inflammatory drug (NSAID).
  • It exhibits analgesic, antipyretic, and anti-inflammatory properties.
  • Understanding its efficacy and safety profile is crucial for clinical practice.

Purpose of the Study:

  • To summarize the pharmacological effects of naproxen sodium.
  • To outline the adverse effects and contraindications associated with naproxen sodium use.
  • To compare the efficacy of naproxen sodium with other common over-the-counter pain relievers.

Main Methods:

  • Literature review of naproxen sodium's pharmacological actions.
  • Analysis of reported adverse events and contraindications.
  • Comparative efficacy assessment of naproxen sodium versus ibuprofen, ketoprofen, acetaminophen, and salicylates for mild pain and fever.

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Main Results:

  • Naproxen sodium demonstrates significant analgesic, antipyretic, and anti-inflammatory effects.
  • Adverse effects include gastrointestinal disturbances, allergic reactions, and potential liver toxicity.
  • Contraindications involve hypersensitivity, heart failure, and hypertension, particularly with fluid retention.

Conclusions:

  • Naproxen sodium is an effective medication for pain, fever, and inflammation.
  • Awareness of its adverse effects and contraindications is essential for safe patient management.
  • Over-the-counter alternatives like ibuprofen and acetaminophen show comparable efficacy for mild symptoms.