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[Keratitis and corneal edema associated with levodopa use--a case report]
K Nakamagoe1, N Ohkoshi, T Fujita
1Department of Neurology, University of Tsukuba.
Rinsho Shinkeigaku = Clinical Neurology
|July 1, 1996
Summary
Carbidopa-levodopa treatment for gait issues may cause reversible keratitis and corneal edema. This eye condition improved after discontinuing the medication, suggesting a potential link.
Area of Science:
- Ophthalmology
- Neurology
- Pharmacology
Background:
- A 34-year-old female patient experienced apraxic gait and difficulty walking following anoxic brain damage.
- Carbidopa-levodopa was administered and gradually increased to manage gait disturbances.
Observation:
- The patient developed blurred vision after 8 days of carbidopa-levodopa treatment.
- Ophthalmologic examination revealed keratitis (corneal endothelitis) and corneal edema.
Findings:
- Carbidopa-levodopa administration was associated with the development of keratitis and corneal edema.
- Discontinuation of carbidopa-levodopa led to dramatic improvement and normalization of vision within 7 days.
Implications:
- This case suggests a potential adverse ocular effect of carbidopa-levodopa, particularly in combination with flecainide acetate and amantadine HCl.
- The reversible nature of the corneal lesion indicates that medication adjustment or cessation can resolve the condition.