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[Mini review: a factor enhanced the antibacterial effect of beta-lactams on methicillin-resistant Staphylococcus
1Clinical Laboratory, Saga Medical School Hospital.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|November 1, 1996
Abstract:
We found a factor (Factor T) in aged mixtures of tungstate and phosphate which greatly enhances the antibacterial effects of beta-lactams on methicillin-resistant Staphylococcus aureus (MRSA), while Factor T alone did not strongly inhibit bacterial growth. The effect on methicillin-susceptible S.aureus was weak. There was no synergism of Factor T with other classes of antibiotics, nor with other groups of bacteria. Factor T is probably a complex of phosphate and tungstate, and reduced the expression of penicillin-binding protein-2', thus sensitizing the MRSA strains to beta-lactams.