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Updated: Aug 11, 2026

Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry
Published on: November 21, 2012
Effects of an AMPA receptor modulator on methamphetamine-induced hyperactivity in rats
J Larson1, C N Quach, B Q LeDuc
1Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697, USA.
Abstract:
The present study tested if a positive modulator of AMPA-type glutamate receptors would counteract the behavioral effects of a drug that enhances the release of dopamine. BDP-29, a compound shown to increase AMPA receptor-mediated synaptic responses in hippocampal slices, markedly attenuated the amount of stereotypic rearings seen in rats after methamphetamine injections. These results suggest that AMPA receptor modulators ameliorate certain aberrant, dopamine-related behaviors and hence may be of interest with regard to schizophrenia.
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